Deep brain stimulation as a way of dealing with severe tremor
The patient was struggling with tremors caused by Parkinson’s disease. The illness interfered more and more with her life and…
Achievements
Research
Scientific research is the basis for understanding the causes, development and treatment of neurological diseases. At the National Institute for Neurological Research (NEUR-IN), we bring together leading-edge facilities and experts from 11 research centres across the country.
Research groups
Publications
2025
A novel Azaspirooxindolinone-based PROTAC for selective BTK degradation and enhanced anticancer activity.
Bio Chem (2025) 157, 108316
2024
AggreProt: A Web Server for Predicting and Engineering Aggregation Prone Regions in Proteins.
Nucleic Acids Research 52: W159-W169.
2025
Antineoplastics for treating Alzheimer’s disease and dementia: Evidence from preclinical and observational studies.
Med Res Rev (2024) 44, 2078–2111
2025
Automated Engineering Protein Dynamics via Loop Grafting: Improving Renilla Luciferase Catalysis
ACS Catalysis 15: 3391-3404.
2025
Differentiation of SH-SY5Y Cells into Cortical Neuron-like Cells for Tauopathy Modeling and Seeding Assays.
Mol Neurobiol (2025)
2025
Early functional changes in lewy body dementia: roles of dynamics, locus coeruleus, and compensation.
Alzheimer's Research & Therapy, 17, 199.
2025
Early social deficits in TgF344-AD rats are accompanied by sex-specificparvalbumin-positive interneuron reduction and altered brain oscillationsin the hippocampal CA2
Neurobiology of Disease 208 (2025) 106875
2025
Inflammation, Autoimmunity and Neurodegenerative Diseases, Therapeutics and Beyond.
Curr Neuropharmacol (2023) 22, 1080–1109.
2025
Moldina: a Fast and Accurate Search Algorithm for Simultaneous Docking of Multiple Ligands
Journal of Cheminformatics 17: 61.
2025
Structural and functional insights into the selective inhibition of mutant tau aggregation by purpurin and oleocanthal in frontotemporal dementia.
Protein Sci (2025).
2024
Advancing assessment of cognitive change in multiple sclerosis: Seeking valid and sensitive approaches beyond simple cut-offs
[Letter]. Multiple Sclerosis Journal, 30(2), 276-278.
2024
Exploring digital speech biomarkers of hypokinetic dysarthria in a multilingual cohort
[Article]. Biomedical Signal Processing and Control, 88, 11, Article 105667.
2024
Isotopic Depletion Increases the Spatial Resolution of FPOP Top-Down Mass Spectrometry Analysis
[Article]. Analytical Chemistry, 96(4), 1478-1487.
2024
Low prevalence of neural autoantibodies in perioperative cerebrospinal fluid samples of epilepsy surgery patients: A multicenter prospective study
[Article; Early Access]. Epilepsia, 11.
2024
Mild behavioral impairment in early Alzheimer’s disease and its association with APOE and BDNF risk genetic polymorphisms
[Article]. Alzheimers Research & Therapy, 16(1), 11, Article 21.
NESPI
National Expert Group for Innovative Treatment of Neurological Diseases.
NESPI was established within the National Institute for Neurological Research (NEUR-IN). This group consists of leading Czech experts from various fields. From physicians and researchers to specialists in legislation, ethics and economics. Together they focus on modern approaches to the treatment of neurological diseases. Their work contributes not only to the availability and safety of innovative treatments in the Czech Republic, but also to their ethical and transparent implementation in practice.
What has already been done?
Achievements
Hello, phone, do I have “Parkinson’s”? The app detects diseases from the call
Just a few minutes of ordinary phone calls may be enough for a unique mobile app to detect Parkinson’s disease in its…
Achievements
Brno triathlete raises over half a million for Alzheimer’s and Parkinson’s research
Scientists from the National Institute for Neurological Research (NEUR-IN) took over the award on Monday 27. January 2025 a cheque in…