International Clinical Research Center, St. Anne’s University Hospital Brno, Brno
Research objectives:
The main objective of this WP is to uncover the bidirectional relationships between the progression of Alzheimer’s disease and circadian system disruption. The specific objectives are as follows:
– Compare the effect of different types of circadian disruption on the progression of AD-like neurodegeneration and behavioral impairments
– Investigate the effect of idiopathic disruption of sleep pattern on neurodegeneration and behavioral impairment progression
– Examine the therapeutic potential of circadian synchronization enhancement via pharmacological and environmental drive