First Department of Neurology, St. Anne’s University Hospital and Faculty of Medicine, Masaryk University, Brno
RECETOX – Faculty of Science, Masaryk University
Research objectives:
– Characterize the microbiota composition of the gut, the oral and nasal cavity in patients with AD and LBDs across the clinical spectrum (changes between mild and advanced stages of NDs), its dynamic changes over time (3y prospective longitudinal study) and the differences in microbiota between the amyloidopathies and synucleinopathies
– Identify which microorganisms in the body may influence the brain processes (nasal, oral & gut–brain axis) and describe the possible pathological processes leading to brain activity alterations which could contribute to neurodegeneration, i.e. amyloid, synuclein or tau deposition (using mice disease models, gut organoid models, see in our other studies)
– To define the relationships between microbiome composition (taxonomic and functional activity) and disease biomarkers and clinical outcomes in patients with NDs; 4. Results of this study are planned to be used for preparation of interventional study with gut and oral probiotics as targeted microbiome-modulating therapy of NDs with CI.