Faculty of Medicine in Pilsen, Charles University, Pilsen
Research objectives:
– How is the neural information processing in hippocampus affected under reduced brain oscillations? Hippocampal and neocortical spiking activity is organized in various rhythmic modes that provide a temporal scaffold for effective information processing. Here we will reduce the dominant oscillation (theta. 9-12 Hz) in hippocampal system by silencing neural activity in medial septum and test how this manipulation affects effectivity of memory recall kinetics on the neural network level
– How the direct brain stimulation (DBS) in the theta range within the hippocampal memory system affects the spatial memory code processing in a models of dementia? Here we will use the DBS approach to reinstate the physiological cell activity