Institute of Physiology CAS
Institute of Organic Chemistry and Biochemistry CAS
Research objectives:
Delineation of the interactions of cholesterol and neuroactive steroids with muscarinic receptors as a pharmacological goal of enhancing cholinergic signalling that is weakened in neurodegenerative processes including AD. To gain new knowledge on the allosteric modulation of muscarinic receptors by cholesterol and neuroactive steroids for the structure-guided design of positive allosteric modulators of M1 muscarinic receptors.