Laboratory of Neuroglial Interactions, Second Faculty of Medicine Charles University
FOCUS AND RESEARCH OBJECTIVES
We are interested in the mechanisms of interactions between neurons and oligodendrocyte lineage cells under different physiological and pathological conditions, especially in epilepsy. Recent findings have suggested that neuronal activity can regulate the number of oligodendrocyte lineage cells and their myelination activity which might have a profound feedback effect on neuronal activity and circuit function. Many pathologies of the central nervous system are accompanied by changes in myelin content in the nervous tissue, including epilepsy, where hypomyelination is usually described. Our goal is to find out how pathological neuronal activity in epilepsy affects the function of oligodendrocyte lineage cells and myelin formation.
Research objectives:
– Neuron – oligodendrocyte precursor cells synaptic communication
– Myelination in epileptic tissue
– mTOR hyperactivity in glial cells