Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc
International Clinical Research Centre, St. Anne’s University Hospital Brno, Brno
Research objectives:
– To collect biological samples from patients with neurodegenerative disorders or the different risk groups such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) and corresponding control samples, age and sex-matched, undergoing clinical examination for other reasons.
– To prepare a database of patient’s samples and their clinical data in a specialised ClinData database proprietary developed at the IMTM.
– To perform a proteomic discovery analysis of tears versus other biomaterials of patients from particular disease/therapeutic groups and controls – analysis of the patient samples and corresponding control samples. To identify significantly altered protein profiles in correlation with clinical data, selection of proteins distinguishing control and patient samples.
– Development of the panel of the protein biomarkers based on the results of the discovery phase and on the currently published data in the literature.