Faculty of Medicine, Masaryk University, Brno
Research objectives:
The general objective of this project is to establish a working pipeline for modeling neurodegeneration diseases using iPSCs, followed by their functional phenotyping to identify potentially relevant targets for pharmacological interventions and proof-of-concept studies.
To fulfill this general objective, we propose the following specific aims:
– Create iPSCs with AD-causing pathogenic mutation
– Differentiation and aging of iPSCs-derived 2D neurons and 3D organoids
– Phenotyping and functional experiments