Department of Neurology, Charles University, Second Faculty of Medicine and Motol University Hospital, Prague
Memory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University
Research objectives:
– To obtain precise and complete characterization of trophic and degenerative factors and PAI-1/tPA changes during the development of neurodegenerative processes and define their role as biomarkers
– To validate the use of peripheral levels of the proteins involved in this pathway to characterize disease stage and disease outcome in neurodegeneration by association with neuropsychological and neuroimaging data