International Clinical Research Center, St Anne´s University Hospital, Brno
Research objectives:
– We aim to transfer fecal material from demented and non-demented Parkinson’s disease patients to our well-established progressive intragastric rotenone mouse model.
– We want to study the effect of altered microbes on rotenone-induced alpha-synuclein accumulation induction using diffusion kurtosis imaging and immunohistochemistry, which will be later correlated with memory impairment.
– Further, we would like to perform metabolomics in the hippocampus and cortex after fecal material transfer from demented patients in rotenone-treated mice to check the alterations in neurogenesis and metabolites